Scientists create mouse model for the study of a couch potato and muscle function

Have revealed Daniel Kelly, MD, and colleagues at the Sanford-Burnham Medical Research Institute (Sanford-Burnham) at Lake Nona surprising new model for studying muscle function: the couch potato mouse

While these mice maintain normal activity and body weight, and do not have the energy to exercise. In this Dec. 1 issue of cell metabolism, and reports of the team, Dr. Kelly is what happens when muscle tissue lacks PGC – 1, a protein coactivator that muscles need to convert fuel into energy.Best Formula Fat Loss Factor

“Part of our interest in understanding the factors that allow muscles to exercise is to know that whatever is in this device, it becomes inactive in obesity, aging, diabetes and other chronic diseases that affect mobility,” explained Dr. Kelly.

Normally, physical stimulation boosts PGC – 1 activity in muscle cells, which switches on genes that increase fuel storage, ultimately leading to muscle “trainers” (the physical condition most people hope to achieve through exercise).
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In obese individuals, PGC – 1 levels drop, possibly further reducing a person’s ability to exercise – creating a vicious circle. In this study, mice without muscle seemed PGC – 1 normal and walked around without difficulty, but cannot run on a treadmill.


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